NJ MAN GENETIC TEST CONFIRMS LYNCH SYNDROME

"Hi Doctor Roshin. This is the official paperwork about my Lynch diagnosis." 
( Mr. Bruce, New Jersey) 

Dear Mr. Bruce, 

Before I begin any explanation on your sent paperwork, do know that with knowledge, "you can beat cancer." God has afforded you this gift of knowledge, and by knowing the diagnosis, you now have the ability to manage and most importantly, help prevent, if not eliminate the possible manifestations, from cancer. 

Your genetic test was positive for a clinically significant mutation (c.454-13A>G) in the MLH1 gene, which has a direct link to a high risk of colorectal and gastric cancers and an elevated risk of pancreatic cancer. Individuals who carry the mutation in the MLH1 gene have Lynch Syndrome, a condition often referred to as hereditary non-polyposis colon cancer. Men and women with Lynch syndrome have an increased risk of developing colorectal cancer, often at a young age. In fact, there is a 52-82% increased risk of colorectal cancer, as compared to the general population risk of 1.9%, in those people with the MLH1 gene mutation. Females with Lynch Syndrome due to the mutation in the MLH1 gene, have an increased risk of endometrial and ovarian cancer. Additionally, people with Lynch syndrome caused by a mutation in the MLH1 gene, have an increased risk of developing a spectrum of secondary cancers not limited to the following: small intestine, gastric, ureter, pelvic, hepatobiliary tract (liver), brain (glioblastoma), sebaceous gland, and pancreatic. 

Although there are high risks for cancer in patients with Lynch syndrome, many of the risks can be diminished with prompt and steadfast medical guidance and management. Now that you are aware of an increased risk of colorectal cancer, what should you do? Talk with your physician about having a colonoscopy done every 1-2 years searching for polyps (adenomatous), the lesions that lead to colon cancer. If a polyp is found, the gastroenterologist can remove the polyp immediately during the colonoscopy procedure. In addition, a surgical consult should be considered, on an individual basis, to evaluate those parts of the colon which may need to be resected. Finally, the National Comprehensive Cancer Network has suggested that aspirin may decrease the risk of colon cancer in Lynch Syndrome patients; however, there is not enough data to sufficiently make a recommendation for its standard use; yet, this would be a conversation worth having with your physician. Management of Lynch Syndrome will be individualized based on each your and each patient's medical history. 

Knowledge is a powerful entity when used resourcefully. Thus, channel the knowledge of your diagnosis into methods to prevent the side effects of cancer or cancer altogether. You live a rich, quality filled family life, and with support of doctors and new research methodologies, you can easily add years of longevity for a continued robust existence. Thank you for your sharing your story with the world and thank you for your trust. God Bless you and God Bless New Jersey. 


Respectfully, 







Dr. Roshin









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       * GAY MUSLIM TEEN ASKS IF A CURE EXISTS?


"Hey Doc. Does low prenatal  testosterone cause homosexuality in males?  I am so.  My family are rejecting me."  ("Asim", England)

Dear "Asim,"

Upon exposure to certain hormones, fetal sex differentiation occurs; thus, male and female organs grow.  This is a known fact; however, your question addresses "the hormonal theory of sexuality and gender identity", which postulates that hormones also play a role in sexual orientation and eventual  gender identity in adult life.  Is this theory true?  Well, the theory itself originated from abundant research studies using mammals, not human beings, and what was researched and concluded is that  prenatal factors and hormones that interact with the developing brain does show sex-typed behavior in children.  Whether the mammal correlation can be linked to humans is highly controversial.  Recently, a 2010 study published in the "Trends of Cognitive Sciences" magazine, entitled " Sex-related variation in human behavior and the brain" did lend support in humans that prenatal androgen exposure influences eventual childhood sex-typed behavior.  Realize that in addition to hormones, sexual orientation has been linked to genes, SRY and ZRY.  Thus, to answer your question " Does low prenatal  testosterone cause homosexuality in males?" presently, the answer would have to be yes, that possibility exists. 

You indicated that "I suffer from ED" but know that there are medications and techniques to address erectile dysfunction, a condition that has no correlation with homosexual tendencies.  You also asked "Is there anything to fix my gay tendebcy?"  The answer is no, there is no medication or treatment to fix lesbian or homosexual desires. 

You also mentioned "I think my strong homosexuality could be as a result of many many strict generations of suppression of those feelings in the DNA in the Islamic side of my family."   There are many religions and cultures with strict forbiddance of  gay and or lesbian lifestyles; yet, in my opinion, religion should stand neutral in this area of genetics.  If a person is attracted to an individual of the same sex, I have written in the past that "no  law can legislate genetics."  Both politics and religion should realize that both entities risk discrimination and intolerance without undoing strict policy or scripture. 

Asim, you have shown much courage to express your true inner feelings; thus, for your own mental health, you must surround yourself with people who support who you are as an individual.   Let your faith help guide your journey, realizing any scripture that unintentionally or purposely condones hatred and violence, is an interpretation of man, not God.  Congratulations on taking your first big step.

I am deeply humbled by your trust in me on an issue that is both sensitive and controversial.   God Bless you.

Respectfully,

Dr. Roshin

        * ALBANIA TEENAGER ASKS WHY HER LEUCOCYTE COUNT IS HIGH?

" My friend said you will help me.  i would be really grateful if you could give me an explanation.  I'm sending you the picture of my blood test. ok. as seen in the test, my number of leucocites is high (all doctors here say that but none of them gives me an explanation why it is so high). So I would like to know any reason for that. Furthermore I look always pale, I've been two years ago anemic, I am weak( I mean not drastically but still comparing to how I have been it is obvious i've lost weight) and I have really big pimples under my armpits which cause me pain and this pimples have appeared firstly one year ago. But i really have many. I did an eco of them but they told me that it is nothing serious,but i thing this can be rel;ated to the high number of leucocites,as long as these pimples are infected.  ahah yes,sorry for such a long msg."  (Bryana, Albania)

Dear Bryana,

After you sent your blood test paperwork, I am glad we had a chance to visit allowing you to ask all your questions.  Your blood results due indeed reflect ongoing anemia.  Since you said "no, never had" blood in your urine, stool, or orally, the immediate explanation for your low  hematocrit and red blood cell (rbc) levels is confirmation that "yes I do" have periods.  Even at age 14, you lose much blood in the menstrual cycles, a rationalization for why " I look always pale, I've been two years ago anemic, I am weak."    Blood carries oxygen, and oxygen is needed for all organs in the body to survive.  When you have a cycle, you lose blood, therefore, you lose oxygen, and the pale complexion along with feeling weak and tired results.  What can you do?  Eat foods high in iron and folate and consult with your doctor about taking iron supplements if diet changes do not bring your rbc and hematocrit levels back to normal.  Red blood cells carry iron,  iron binds the oxygen, and as mentioned, oxygen gives your body energy to survive.  Thus, as I am sure you can now understand, during a cycle , you lose not only red blood cells, you lose iron also.

With regards to your question, " my number of leucocites is high" and "So I would like to know any reason for that."  Actually, Bryana, according to your blood results, your lymphocyte count is LOW, not high.  Lymphocytes are a type of white blood cell (leucocyte), and white blood cells are the "good guys" in the body that fight infection.  When your lymphocyte count (LYM%  on paperwork) is low, the most likely explanation is your immune system needs a boost.  When your immune system is under performing, you are at slightly increased risk for infections, especially viral.  Thus, to boost your immune system, eating and exercising are two factors, in your control, to boost overall health.  Eating healthy foods is by far the easiest way to boost the immune system.  Take vitamins, do not smoke, eat a diet high in fruits and vegetables, eat whole grains, and eat foods low in saturated fat.  In addition, exercise regularly, to maintain a healthy weight.

With regards to your question, "what kind or amount of blood should I consume?  I mean I have hears them say that there are different kinds of iron."   You asked a good question.  Actually, you would not consume blood as a means to obtain dietary iron; instead, you should consume lean cuts of meat (chicken, turkey, beef) to try to regain the daily recommended amounts of iron your body requires to optimally function.  If the diet changes do not increase iron, talk to your doctor about iron supplement tablets.   Also remember to wash your hands frequently to help prevent infections from entering your body.

You are a very intelligent young lady, and I am humbled by your questions and trust.  Please stay in touch, and if other people in Albania have health questions, please feel free to reference them to me.  God Bless you and God Bless Albania.

Respectfully,

Dr. Roshin

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  PHILIPPINE LADY LIVING IN SAUDI ARABIA ASKS FOR HELP.   HAS PERICONITIS

"Hi Doc.. Doc please advice me on how to cure a swollen gums around my wisdom tooth😢😢.. It's really painful and I just try to ask you of any home remedies. I can't eat or even drink water. It's really hardto swallow because I felt that my throat is swollen too..  Please Doc.. thank you.."  (Ms. Mary, Philippines)

Dear  Ms. Mary,

After visiting with you, with urgency on Facebook this past weekend,  more than likely, your wisdom teeth need  removal.   Wisdom teeth are given that name due to typically growing during adulthood years.  You said " Im 28 yrs old doc.."  However, not everyone is able to keep these teeth due to a small mouth size causing both crowding and improper growth of teeth.  However, my conclusion was established after you mentioned " Lower jaw left side Doc.. Yesterday doc i felt it was swollen and pain.  my wisdom teeth i felt it was painful and hurt when i try to touch it from my tongue." 

When I asked are you having difficulty breathing, you said " No Doc.."  In addition, you said  " I dont have fever today,  Its painful Doc when it (a toothbrush) touch.., No blood so far Doc (in saliva),  but i felt lately that Im having a headache.. Doc it really hurt me so much."   Finally, when I asked you "does every tooth hurt or only the wisdom tooth on your left lower jaw?"  you said, "Only the wisdom tooth as well as the gums Doc.."  Your swollen gums might indicate a condition called pericoronitis, inflammation of the tissue surrounding the wisdom tooth.

Both the possible extraction (pulling out) of all four wisdom teeth along with diagnosing and treating a possible pericoronitis requires a clinical examination by a dentist.  I realize you are working in Saudi Arabia and are "afraid that it will affect my work here in Saudi.." but the pain you are presently feeling will get worse if you do not immediately visit a dentist.   Thus, I am glad to hear " But I can try to ask permission to go to a dentist Doc..buy for now i want any temporary cure for this pain and hurt I felt.."

Since you "dont had any allergic reactions " there are some home remedies that can temporarily help with pain until you see a dentist.  These remedies include clove oil, peppermint tea bags, vanilla extract, hydrogen peroxide rinse, garlic, salt water treatment, and a liquor (alcohol)-soaked cotton ball.  

Since you mentioned certain items you already have at your home, these are temporary treatments to help decrease the pain.  Mix a crushed garlic clove (or garlic powder) with some table salt or black salt and apply it directly on the affected tooth to alleviate the pain.  If you prefer, you can chew a clove or two of garlic to get relief.  Onions have antiseptic and antimicrobial properties that control a toothache. It can provide relief from pain by killing the germs causing an infection.  Chew raw onion for a few minutes to relieve the pain. If you are not able to chew onion, place a piece of raw onion directly on the bad tooth or gums.  Mix half a spoon of common salt in a glass of hot water and rinse your mouth thoroughly.  The salt water will help reduce swelling and inflammation, as well as fight the bacteria that cause infection.

I was glad to hear " I will try the onion Doc..Thank you so much for your concern, God be with you always Doc..I will surely update you Doc.."  Keep well Mary.  God Bless you, God Bless Saudi Arabia, and God Bless the Philippines.  

Respectfully,

Dr. Roshin

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Thank u so much Doc..😊😊😊

Mary Aneesa Abayon

Received: August 7, 2016







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   * NEW JERSEY FATHER ASKS WHY SON'S LYNCH SYNDROME NOT DIAGNOSED EARLY ? WHAT TREATMENTS?

“Hi Dr. Roshin.  I'd like to invite you to my house. My wife is a Japanese girl XOXO. She makes life wonderful and she's a real good cook.  The patient is my son Raymond. He's 27 and married. By the way I'm fortunate enough to have all 4 of my children living with me and plus the 2 wives of my sons. About a year ago the pains became too much and when Raymond went to the emergency room, it took awhile but they discovered a problem. They ended up removing the descending part of the colon. Raymond had the bag and went through about 4 or 5 months of chemo. After a few more months they did an operation to reattach him and discovered more cancer on the small intestine. As I was explaining I'm adopted along with my half brother and sister. We are all from the same mom. They both experienced colon cancer in there 40's. My sister got a positive report for Lynch Syndrome pretty recently. Although we've suspected for awhile. I assume I must have it. One strange thing is that the first report from the Dr's said that Raymond did not have it. And when I showed them my sisters report then they said he did. I assumed it would be more black and white. Dr. can you check about Radio Surgery. Dr. Gil Lederman is on the radio 710 am. Thats the station. Gotta head to work. Good luck in your ministry. God Bless You --- Bruce and XOXO"

Hello Mr. Bruce,

I have to admit, I am baffled by your comments that your son’s Lynch syndrome was not the initial diagnosis afforded by his doctors, with expedient treatments, both screening and curative, provided as early as possible.  Lynch Syndrome, often referred to as hereditary nonpolyposis colorectal cancer (HNPCC), is the most common inherited cause of colon cancer; thus, from the onset, your son’s family history, in other words, his genetic history should have been extensively explored, with an immediate realization that a link to his present symptoms exists.  In fact, for people with Lynch syndrome, colonoscopy cancer screening exams should be scheduled every one to two years beginning in their twenties.  Time is survival; thus, excuses and apologies are unacceptable.  Your son developed colon cancer of the descending colon, which was appropriately resected, used a colostomy bag for four to five months, and underwent a successful surgery to reattach the digestive system tract.  However, during that reattachment surgery, cancer was found in the small intestine, and you wish to discuss radiosurgery. 

Radiosurgery is a procedure that targets tumors using a large dose of radiation, focused on that precise cancerous lesion, for eradication.  Since the high dose of radiation is localized to a small area, as opposed to chemotherapy which floods the body with toxic medication to kill the cancer cells, radiosurgery would be an effective procedure for Raymond’s small intestine cancer.  Radiosurgery, in combination with chemotherapy, is often more effective to ensure total purging of the cancer from your son’s body.  However, the radiosurgery procedure does render many adverse complications not limited to the following:  skin blisters, inability to hold bowel, fatigue, erectile dysfunction in males, vaginal irritation in females, blood in stool, painful bowel movements, and urinary irritation (burning, blood in urine).  There are multiple treatment options on how to deliver the radiation, as well as numerous other treatments options available for bowel cancer; thus, a final decision should only be made after contemplation with Raymond’s physician.

Bruce, I am humbled by your invitation to visit your family.  Thank you for your question(s) and trust.  Please stay in touch, as I wish to know your family’s final treatment decision and most importantly, the outcome.  If you have any questions or simply need a second opinion, feel free to call or write, at your convenience.  In the meantime, although I do not have a ministry, your thought sounds like a reasonable calling, worth considering.  God Bless Raymond, God Bless you, and God Bless New Jersey.

Respectfully,

Dr. Roshin

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PHILIPPINE LADY ASKS WHY HER MOTHER'S KIDNEYS SHRINKING

“ Hi Roshin, I would like to ask, my mother went through an ultrasound and the doctor said the left kidney of my mother is getting smaller.  May I ask what kind of illness is that? this time, they did not yet gave any medicine but only buscopan hyocine and vitamins only. What will I do next? please help me how to find cure for my mother, what to do and where doctor will we go. Thank you.. i'm quite nervous and worry of what will you say regarding the result of my mother's ultrasound, I hope she can be cured the soonest. thank you for finding some time for my mother's case.. I will be online tonight until midnight to catch your time.  gratefulness is mine.. from the bottom of my heart.. my sincere thankfulness to you//”  (Ms. Evelyn, Philippines)

Dear Evelyn,

I am glad we visited on Facebook this past weekend.  After viewing your mother’s ultrasound report and gathering her pertinent medical history from you, your mother’s present day health course has a direct link to past conditions; however, her test results do not indicate any glaring medical concerns, as long as she maintains her prescribed, treatment regimen.

 Specifically, you mentioned your mother has “maybe 20 yeas” of hypertension, and is taking “Plendil 5 - once a day.”  In addition, you mentioned that your mom is taking “vestar twice a day” for “she had chest paint maybe from 6 months.”  You mentioned she had high cholesterol of “300” but “after taking prabastatin, yes they get normal now.”  You said “she loves to eat meat before, mostly pork mybe 4 times/week, with soup, sometimes fry, we she always use soy sauce.”  When I asked if your mother was a smoker, you said, “before yes, when shes still at age 30 to 45.”   Fortunately, your mother has no history of kidney problems, urinary problems, diabetes mellitus, allergies, or cancers. 

Your mom’s past medical history is directly linked to her present state of health.  The sonography report does indicate “small size both kidneys, good corticomedullary differentiation, but otherwise unremarkable.”  Although the report indicates small sized kidneys, her kidney function tests are normal; thus, there is little concern. 

I am of the belief that your mom’s “smaller kidney size may be due to effects on her blood vessels from her past history of smoking, high cholesterol, and high blood pressure.  Smoking causes direct damage to the vasculature, thus blood flow often slows.  Cholesterol is fatty deposits that accumulate in a blood vessel, also preventing blood flow.   Thus, the combination of smoking and high cholesterol makes blood flow very difficult, and the lack of blood flow, causes a backup of blood in the vessels, leading to hypertension (high blood pressure).  Remember, blood carries oxygen, and oxygen is needed by every organ in the body to survive.  Thus, smoking, high cholesterol, and hypertension decrease blood flow to the organs.  When decreased blood flow affects the heart, chest pains occur. 

Fortunately, your mom’s medication regimen has her blood pressure normal (110/70), no chest pains, and normal cholesterol levels.   Now, all she has to do is make lifestyle modifications.   Since she is an 80 year old ambulatory woman, she should take a 15-30 minute walk, if tolerable, every day to help keep her heart healthy.   In addition, you mentioned, “she loves to eat meat” however, your mom needs to limit her meat intake to 1 or 2 servings per week.  Instead of eating pork, she should consider eating lean cuts of poultry as well as seafood.    After our discussion on the importance of a diet change, I am glad to hear that you also agree, “she need to shun from those.”  Eating plenty of fruits and vegetables will also keep her heart healthy, decrease cholesterol, and maintain normal blood pressure.  Please consult a doctor in your area before beginning an exercise regimen or beginning any treatment plan. 

The bottom-line is that your mom’s longevity is in her own hands.  Improved eating habits, a tolerable, exercise regimen, and taking her medications as directed, will literally add years to her life.  Surrounding your mom with family support will keep her mental state healthy too.  Thank you for your question and trust.  God Bless your mom, God Bless you, and God Bless the Philippines.

Respectfully,

Dr. Roshin

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         "THE MAGIC CURE FOR HCV"  - ONE MAN'S STORY

Doctoradvisor,

"As per your request, I have written a brief story of my experience with the HCV.  I hope this helps some of your readers and wish all of them the best in their quest to eradicate this awful disease."

Cordially,

R.S. (Newark, NJ)

"Harvoni - THE MAGIC CURE for HCV"

I had originally heard about the "MAGIC CURE' in 2012.  I was dealing with Hep C since 2002 (at least that was the year it was discovered) and it was rapidly deteriorating my liver.  My prognosis was not encouraging.  My first severe episode was in February of 2007 when the varices ruptured on my esophagus.  Chance of survival is about 30% but I was fortunate.  They were banded and I lived.  

That was the beginning of the journey.  I had episodes with hepatic encepolopathy and they became more frequent as time went by.  I was moved from Monmouth Medical to University Hospital, and they were able to save my life there.  

The Harvoni treatment was approved by the FDA on December 8, 2013.  I was blessed with a most outstanding Hepatologist, who got me into the program in February of 2014.  At that time my viral load was in the multi-millions.  At the end of the program, no virus was detected.  A true miracle.  My prognosis before treatment indicated that I did not have much time left.  After treatment, prognosis is 15 years or better.

The big issue with the treatment is it's cost.  I was on an 8 week program that cost close to $100,000.  That's something like $1,300 a pill...and you take 2 a day.  Hopefully the cost comes down and everyone can get the treatment.  It is a true miracle.  My doctors now have me on a magic cocktail.  To sum it up, I haven't felt this good in many, many years.

Thank you,

Rico (Newark, New Jersey)

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Dear Mr. R.S.,

Thank you for sharing your story with DoctorAdvice4u readers.  You are a walking miracle.

Respectfully,

Dr. Roshin

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